From Chapter 3:
Another tract which may be classed with Venner's "Treatise" was the "Nepenthes or the Vertues of tobacco," by Dr. William Barclay, which was published at Edinburgh in 1614. This is sometimes referred to and quoted, as by Fairholt, as if it were a whole-hearted defence of tobacco-taking. But Barclay enlarges mainly on the medicinal virtues of the herb. "If Tabacco," he says, "were used physically and with discretion there were no medicament in the worlde comparable to it"; and again: "In Tabacco there is nothing which is not medicine, the root, the stalke, the leaves, the seeds, the smoake, the ashes." The doctor gives sundry directions for administering tobacco—"to be used in infusion, in decoction, in substance, in smoke, in salt." But Barclay clearly does not sympathize with its indiscriminate use for pleasure. "As concerning the smoke," he says, "it may be taken more frequently, and for the said effects, but always fasting, and with emptie stomack, not as the English abusers do, which make a smoke-boxe of their skull, more fit to be carried under his arme that selleth at Paris dunoir a noircir to blacke mens shooes then to carie the braine of him that can not walke, can not ryde except the Tabacco Pype be in his mouth." He goes on to say that he was once in company with an English merchant in Normandy—"betweene Rowen and New-haven"—who was a merry fellow, but was constantly wanting a coal to kindle his tobacco. "The Frenchman wondered and I laughed at his intemperancie."

From Chapter 7:
In a World of 1755 there is a description of a noisy, hearty, drinking, devil-may-care country gentleman, in which it is said, "he makes no scruple to take his pipe and pot at an alehouse with the very dregs of the people." In a Connoisseur of 1754 a fine gentleman from London, making a visit in a country-house, is taking his breakfast with the ladies in the afternoon, when they had their tea, for, says he, "I should infallibly have perished, had I staied in the hall, amidst the jargon of toasts and the fumes of tobacco." When Horace Walpole was staying with his father at his Norfolk country-seat, Houghton, in September 1737, Gray wrote to him from Cambridge: "You are in a confusion of wine, and roaring, and hunting, and tobacco, and, heaven be praised, you too can pretty well bear it." But Gray had no objection to tobacco. He lived at Cambridge, and the dons and residents there (as at Oxford), not to speak of the undergraduates, were as partial to their pipes as the men who went out from among them to become country parsons, and to share the country squire's liking for tobacco. Gray wrote to Warton from Cambridge in April 1749 saying: "Time will settle my conscience, time will reconcile me to this languid companion (ennui); we shall smoke, we shall tipple, we shall doze together"—a striking picture of University life in the sleepy days of the eighteenth century. Gray's testimony by no means stands alone. In November 1730 Roger North wrote to his son Montague, then an undergraduate at Cambridge, saying: "I would be loath you should confirm the scandal charged upon the universities of learning chiefly to smoke and to drink."