From Chapter 2:
Hentzner, the German traveller, who visited London in 1598, speaks of smoking being customary among the audience at plays, who were also supplied with "fruits, such as apples, pears and nuts, according to the season, carried about to be sold, as well as ale and wine." He was struck with the universal prevalence of the tobacco-habit. Not only at plays, but "everywhere else," he says, the "English are constantly smoking tobacco," and then he proceeds to describe how they did it: "They have pipes on purpose made of clay, into the further end of which they put the herb, so dry that it may be rubbed into powder; and putting fire to it, they draw the smoak into their mouths, which they puff out again through their nostrils, like funnels, along with it plenty of phlegm and defluxions from the head." This suggests that the unpleasant and quite unnecessary habit of spitting was common with these early smokers, a suggestion which is amply supported by other contemporary evidence.

From Chapter 5:
The belief in the prophylactic power of tobacco was, however, very generally held. When Mr. Samuel Pepys on June 7, 1665, for the first time saw several houses marked with the ominous red cross, and the words "Lord, have mercy upon us" chalked upon the doors, he felt so ill at ease that he was obliged to buy some roll tobacco to smell and chew. There is nothing to show that Pepys even smoked, which considering his proficiency in the arts of good-fellowship, is perhaps a little surprising. Defoe, in his fictitious but graphic "Journal of the Plague Year in London," says that the sexton of one of the London parishes, who personally handled a large number of the victims, never had the distemper at all, but lived about twenty years after it, and was sexton of the parish to the time of his death. This man, according to Defoe, "never used any preservative against the infection other than holding garlic and rue in his mouth, and smoking tobacco."