All-virtuous Herbert! on whose every part
Truth might spend all her voice, fame all her art!—
was a smoker, as we know from a very curious passage in his well-known autobiography. He appears to have smoked not so much for pleasure as for supposed reasons of health. "It is well known," he wrote, "to those that wait in my chamber, that the shirts, waistcoats, and other garments I wear next my body, are sweet, beyond what either can easily be believed, or hath been observed in any else, which sweetness also was found to be in my breath above others, before I used to take tobacco, which towards my latter time I was forced to take against certain rheums and catarrhs that trouble me, which yet did not taint my breath for any long time." The autobiography was written about 1645, so as Lord Herbert did not smoke till towards the latter part of his life—he died in 1648—he clearly was not one of those who took to tobacco in the first enthusiasm for the new indulgence.

From Chapter 6:
William Penn did not like tobacco and was often annoyed by it in America. Clarkson, his biographer, relates that on one occasion Penn called to see some old friends at Burlington, who had been smoking, but who, in consideration for his feelings, had put their pipes away. Penn smelt the tobacco, and noticing that the pipes were concealed, said, "Well, friends, I am glad that you are at last ashamed of your old practice." "Not entirely so," replied one of the company, "but we preferred laying down our pipes to the danger of offending a weaker brother."